Whether the customer’s requirement is for mixing, granulation or drying, Collette™ has a solution for every processing challenge. Collette's UltimaPro™ Single Pot Processor offer a choice of mixing, granulation and drying options integrated into one processing vessel. With Collette's help, this allows the customer to choose the most appropriate technique for the product.

Collette™ has supplied mixing and granulation systems to various industries for more than a century and to the pharmaceutical industry in particular for more than 50 years. Based on this experience, Collette™ supplies advanced solids processing systems for mixing, granulating and drying in the pharmaceutical industry. This includes small capacity systems designed for R & D as well as industrial size plants for batch production of pharmaceutical compounds under cGMP conditions.

Product Know-How – Process Expertise
With the high-shear granulation technology as the basis, Single Pot Processing relies on the application of a vacuum within the bowl to dry the wet mass. This technique allows drying of
pharmaceutical compounds at low temperature, and for minimal environmental exhaust through a very efficient solvent recovery, even if organic solvents are used for granulation.

The vacuum drying process can be enhanced by the addition of a small amount of gas, passing through the product during the drying phase. The gas-assisted vacuum drying (TransFlo™) technique results in shorter drying times and lower residual moisture content of the final product.

To further enhance the drying process, microwaves can be added as an additional energy source. Because of the additional energy added to the process, microwave drying is the fastest drying technique available in One-Pot processing. Through careful control of product temperature and forwarded and reflected microwave power, this technique is ideal for fast processing of pharmaceutical products.

Key Characteristics:

  • Flexible technology for standard wet granulation, melt granulation, pelletizing or effervescent production, combined with vacuum or microwave drying
  • Swinging bowl options during vacuum drying results in an improvement of the granule characteristics and a reduction in drying time
  • Easy and efficient cleaning (CIP)
  • Compact technology – reduce space due to incorporating several processing steps into one machine

Process Control & Monitoring:

  • A range of control systems for maximum level of flexibility and functionality for process visualisation, automation and data recording
  • PAT Integration – Combining process monitoring using online analysers, together with solid process engineering principles and advanced process modelling techniques will
    enable processes to be actively controlled in order to compensate for minor input variations (eg. raw materials) so that the specifications for the final product will be closer to the ideal target.

Containment:

  • The single pot process is a totally contained process
  • No transfer between process steps
  • For loading and unloading BuckŪ high containment split-valve technology
  • Product sampling

From R&D to large scale production

Collette is your partner for your granulation process from process development up to full-scale production. With capacities from 10 l to 1500 l, the UltimaPro™ range can cover all requirements starting with the process development stage and clinical batch production to scale-up trials and large-scale production for marketed products.

Collette UltimaPro™ product range:

  • Development: UltimaPro™ 10/25, batches 1-9kg
  • Pilot Scale: UltimaPro™ 75/150, batches 10-50kg
  • Production Scale: UltimaPro™ 300 to 1500, batches 50-600kg