Single Pot Processors

Single Pot Processing with Collette UltimaPro™
Single Pot processing offers a choice of mixing, granulation and drying options integrated into one processing vessel. With Collette's help, this allows the customer to choose the most appropriate technique for the product. Using proven standard components, Collette™ can supply both simplicity and flexibility in plant design. User-selected process options, control systems and liquid recovery units combine in a system to meet process requirements exactly. This approach ensures that qualification and validation work can be kept to a minimum and secures successful results ... Read more and download

Melt Granulation with polyethylene glycol in a Single Pot Processor
This study compares different processing methods to prepare a melt granulation with polyethylene glycol (PEG) in a high shear mixer / single pot processor. For melting the PEG, either the heated jacket or heated jacket supplemented with microwaves was used to supply the necessary energy. For cooling the mass after granulation, 3 methods were compared: cooling with the jacket, cooling with pressurized air and cooling with liquid nitrogen ... Read more and download

Single Pot Systems for Drying Pharmaceutical Granules
The first single pot units were mixer/granulators retrofitted for vacuum drying. The energy needed for drying was provided by heated jacket water. However, the single-pot system was only accepted by the pharmaceutical industry when drying times were reduced dramatically by microwave (1987) or by gas (1989) assistance. A number of different reasons exist why single pot technology is selected for the production of granules:

• The yield of modern production-scale single-pot systems is far in excess of 99%.
• Organic solvents can be recovered relatively easily, as it is only necessary to treat the pure solvent vapour rather than a large air flow with a small organic solvent concentration as in the case of the fluidized bed process. As the granules are dried in a vacuum atmosphere containing practically no oxygen, the explosion risk is also reduced substantially.
• Where highly active substances are handled, the one-pot process allows a relatively easy protection of the environment because of the fully contained design and the integrated cleaning-in-place systems.
• One-pot units can be used for the aseptic production of granules since the process is fully contained and an additional sterilizing-in-place system can be installed ... Read more and download

Cleaning validation study on the ULTIMAPRO™ Single Pot Processor
The cleaning validation study on the ULTIMAPRO™ 75 has shown that the CIP system of this equipment is capable of removing both the water-insoluble mebendazole and the water soluble theophylline from the machine to a level well below the generally accepted acceptance criteria. Although certain areas show a larger variation in results then others, the reproducibility of the cleaning cycle can be considered good as results for all sampling areas were always consistent ... Read more and download