GEA Pharma Systems - the only supplier that offers the complete range of Granulation and Drying processes
GEA Pharma Systems advanced range of Aeromatic-Fielder™ fluid bed processors, Collette and Aeromatic-Fielder high shear mixers / granulators and Collette™ single pot processors are known throughout the pharmaceutical, chemical and food processing industries of the world for their engineering excellence and technical innovation. GEA Pharma Systems is committed to delivering optimized solutions to meet customer requirements. Built-in versatility of system design is achieved through a wide range of standard options and configurations, for efficient processing and easy integration with up-and down-stream plant. As well as stand-alone equipment and fully integrated plants, the company offers a complete engineering service from system design to process integration and optimisation. In addition we have fully equipped test facilities available for process verification and optimisation.
NEW Innovations
Tomorrow's technology today
- FlexStream™, our new fluid bed system offers multiple processing from a single bowl providing both flexibility and cost benefits.
- Consigma™, a unique continuous granulation and drying process that drastically reduces time to market of new medicines and enables the move to a 6-Sigma process.
- PharmaConnect™ which enables diverse GEA development equipment to be docked into a single ‘plug and play’ module with full cGMP compliance.
Granulation is one of the most important unit operations in the production of pharmaceutical oral dosage forms. However, there are many different technologies each having different strengths and weaknesses. Most companies choose which one to use simply based on their own experience. This article introduces different processes, compares them objectively, offers unbiased advice on the merits of each system and then looks at the implications of selection a particular granulation process. UPDATE 2010: Originally written and published in 2004 by Dr. Harald Stahl, this document has now been updated to include the latest process advancements and innovations in Granulation technology. ... Read more and download
The design of a tableting line able to handle potent APIs in a safe way requires an in depth understanding of the required level of protection. Here the specifics of the API, the dilution with excipients, the containment performance of the equipment and the frequency of operation are the key parameters which are linked by complex interrelations ... Read more and download
High Shear Mixers and Granulators
Aeromatic-Fielder™ High Shear bottom-drive Mixing and Granulation with PMA™ range
The GEA Pharma Systems - Aeromatic-Fielder™ High Shear Mixer and Granulator is a multi-purpose processor equally suitable for high speed dispersion of dry powders, aqueous or solvent granulations, effervescent products and melt pelletization ... Read more and download
Collette™ High Shear top-drive Mixing and Granulation with UltimaGral™ range
Whether the customer’s requirement is for mixing or granulation, GEA Pharma Systems / Collette™ has a solution for every processing challenge. With both low shear planetary mixers and high shear granulators in the range, Collette can help select the technology that is most suitable for the product and process ... Read more and download
PharmaConnect® - the fast way to CONNECT your product development by Aeromatic-Fielder™
PharmaConnect® ‘plug and play’ approach enables a number of diverse process modules from GEA Pharma Systems brands to be docked to ONE control module. The primary processes are based around Aeromatic-Fielder’s PMA™ Granulator technology, providing the user with the ability to process batches from 100g up to 25kg and over ... Read more and download
Fluid Bed Processors
Granulation, Drying, Pelletizing and Coating Fluid Bed Processing by Aeromatic-Fielder™
For nearly fifty years, GEA Pharma Systems - Aeromatic-Fielder™ has supplied advanced fluid bed processing plants for blending, granulating, drying, pelletizing and coating to the pharmaceutical industry. This includes small capacity systems designed for R&D as well as industrial size plants for batch production of pharmaceutical compounds under cGMP conditions ... Read more and download
NEW FlexStream™ Fluid Bed Processor by Aeromatic-Fielder™
Flexible Fluid Bed Processing with FlexStream™ (patent pending) a NEW Multi-Purpose Processor from GEA Pharma Systems – Using proven Aeromatic-Fielder™ fluid bed technology to achieve fluid bed granulation, drying and pellet coating (or tablet coating) in ONE processor ... Read more and download
MP-Micro™ bench-top Fluid Bed Processor by Aeromatic-Fielder™
Purpose-designed for R&D projects, the MP-Micro™ Fluid Bed brings all the flexibility of a full-size production fluid bed processor to the laboratory benchtop ... Read more and download
In-line process analysis of residual moisture in a Fluid Bed Granulator / Dryer using NIR Spectroscopy (Technical article)
The authors describe the in-line moisture measurement of a pharmaceutical granulation of lactose, microcrystalline cellulose and crospovidone in a fluid bed granulator dryer using top sprayed granulating liquid ... Read more and download
Fluid Bed Precision-Granulation™ as an Alternative Granulation Method (Technical article)
Fluid Bed Granulation and High Shear Granulation are presently the most important wet granulation techniques employed in the pharmaceutical industry. Precision-Granulation™, a new bottom spray method, is evaluated for comparison with the conventional granulation methods ... Read more and download
Up-scaling of Fluid Bed Processes (Technical article)
As a result of the FDA PAT initiative an increased interest in process understanding is seen in the pharmaceutical industry. Also a rising interest in “consistent” processes is noticed. Aim is that during pharmaceutical processing each particle should undergo the same experience independent of equipment or scale of operation. This paper reviews the consequences of transferring a fluid bed process from scale 1 to a larger scale 2 ... Read more and download
Single Pot Processor
Collette™ Single Pot Processor with UltimaPro™ range
Whether the customer'srequirement is for mixing, granulation or drying, GEA Pharma Systems - Collette™ has a solution for every processing challenge. Single Pot processing offers a choice of mixing, granulation and drying options integrated into a single process vessel ... Read more and download
Melt Granulation with polyethylene glycol in a Single Pot Processor (Technical article)
This study compares different processing methods to prepare a melt granulation with polyethylene glycol (PEG) in a high shear mixer / single pot processor. For melting the PEG, either the heated jacket or heated jacket supplemented with microwaves was used to supply the necessary energy. For cooling the mass after granulation, 3 methods were compared; cooling with the jacket, cooling with pressurized air and cooling with liquid nitrogen. The results of the comparison show a significant time reduction in the process when using microwave energy for heating the product, and liquid nitrogen for cooling. No differences in granule particle size distribution could be observed ... Read more and download
Single-Pot Systems for Drying Pharmaceutical Granules (Technical article)
This paper reviews single-pot systems for the production of solid dosage drugs in the pharmaceutical industry. A discussion of the underlying physics is followed by a detailed review of the drying processes. The paper concludes by a comparison of the different techniques based on published data ... Read more and download
Cleaning Validation Practices: using a Single Pot Processor (Technical article)
This paper describes the results obtained on a Single Pot Processor related to cleaning and cleaning validation of two drug compounds: water-soluble theophylline and water-insoluble mebendazole. Both substances were produced using high-shear wet granulation and microwave drying, the Single Pot Processor was then cleaned using its Clean-In-Place system, without operator intervention. Swab samples were taken from areas considered critical during processing and analyzed for remains of the active ingredient. It was concluded from the results that the processor’s CIP system is capable of removing both substances to a level well within generally accepted regulations ... Read more and download
Continuous Granulation and Drying
CONSIGMA™ Continuous Granulation and Drying
Continuous high shear granulation and drying with CONSIGMA™ leads the way to a risk based approach and lean manufacturing. Process know-how and control on a micro-scale results in guaranteed quality, avoiding end of line testing and allowing for parametric product release. Full flexibility in batch size (simply by adjusting the time of production) enables you to produce your products to meet demand ... Read more and download
Integrated solid dosage production
Effervescent Dosage Manufacturing (Technical article)
Effervescent tablets are an interesting pharmaceutical dosage form, offering some unique advantages when compared with simple tablets. However, the manufacturing process involves some critical steps that need to be addressed carefully during formulation and factory design ... Read more and download
Reducing the risk of drug development and production for Synthon BV
(Customer case study)
GEA Pharma Systems (GPS) formerly known as Niro Pharma Systems, part of the GEA Group, has helped develop a complete process line for one of Europe’s most successful pharmaceutical companies for the manufacture of generic medicines. The pellet processing project includes the supply and integration of; high shear granulation technology with a UltimaGral™ and NICA™ Pelletizing System, coating technology with the Aeromatic-Fielder™ unique PRECISION COATER™ and fluid bed drying ... Read more and download
Safety 1st - with new 16 bar High Shear Granulators from Aeromatic-Fielder™ and Collette™ (Technical article)
GEA Pharma Systems (formerly known as Niro Pharma Systems) in conjunction with FSA, the safety specialist centre in Germany, have carried out an extensive test program involving over 100 test explosions. This research has shown conclusively that should an explosion occur during the transfer operation in an integrated system where a granulator is connected directly to a fluid bed dryer without an explosion isolation valve then, the secondary explosion pressures in the granulator can be significantly higher than in the fluid bed ... Read more and download